Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC070
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-11 12:46
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Mirapexin a 1,02mg 1x1 tbl Mirapexin a 0,52mg 1x1 old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 7 individuals with a value less than 0.53 were subsequently diagnosed with PD. That is, 16.67% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.53 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 22, 'TN': 17, 'TP': 20, 'FP': 13}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 16, 'TN': 11, 'TP': 26, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 0, 'TN': 0, 'TP': 42, 'FP': 30}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 5.452
timePerCircleCoV 0.118809
timePerCircleSlope -0.0355277
meanError 1.67207
tremorFreq 5.85938
tremorRelPower 25.1421
tremorGyroAmpMean 0.026401
tremorGyroAmpSlope 0.000375384
tremorGyroAmpCoV 0.383567
tremorCoordAmpMean 0.0566817
tremorCoordAmpSlope -0.00280283
tremorCoordAmpCoV 0.309211
tremorAccAmpMean 0.0575405
tremorAccAmpSlope -0.000712643
tremorAccAmpCoV 0.162986
tremorPcRelVar 0.642902
tremorPcX 0.0902316
tremorPcY -0.995921

Circle Segment 1

Duration 6.64 s, Accuracy Estimate 2.623 (lower is better)

Circle Segment 2

Duration 6.36 s, Accuracy Estimate 1.357 (lower is better)

Circle Segment 3

Duration 5.52 s, Accuracy Estimate 1.604 (lower is better)

Circle Segment 4

Duration 5.72 s, Accuracy Estimate 1.475 (lower is better)

Circle Segment 5

Duration 5.6 s, Accuracy Estimate 1.431 (lower is better)

Circle Segment 6

Duration 4.92 s, Accuracy Estimate 1.378 (lower is better)

Circle Segment 7

Duration 4.92 s, Accuracy Estimate 1.302 (lower is better)

Circle Segment 8

Duration 5.12 s, Accuracy Estimate 1.563 (lower is better)

Circle Segment 9

Duration 5.04 s, Accuracy Estimate 1.269 (lower is better)

Circle Segment 10

Duration 4.68 s, Accuracy Estimate 2.718 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 12.7
timePerSpiralCoV 0.0937181
timePerSpiralSlope -0.0109759
meanError 1.98172
tremorFreq 6.93359
tremorRelPower 26.0752
tremorGyroAmpMean 0.0334165
tremorGyroAmpSlope 0.0016677
tremorGyroAmpCoV 0.306011
tremorCoordAmpMean 0.0738012
tremorCoordAmpSlope 0.00264601
tremorCoordAmpCoV 0.430494
tremorAccAmpMean 0.0453146
tremorAccAmpSlope 0.00177429
tremorAccAmpCoV 0.303083
tremorPcRelVar 0.536916
tremorPcX 0.603127
tremorPcY -0.797645

Spiral Segment 1

Duration 13.6 s, Accuracy Estimate 1.814 (lower is better)

Spiral Segment 2

Duration 11.96 s, Accuracy Estimate 2.014 (lower is better)

Spiral Segment 3

Duration 13.44 s, Accuracy Estimate 2.105 (lower is better)

Spiral Segment 4

Duration 13.2 s, Accuracy Estimate 1.907 (lower is better)

Spiral Segment 5

Duration 12.08 s, Accuracy Estimate 1.692 (lower is better)

Spiral Segment 6

Duration 12.84 s, Accuracy Estimate 2.143 (lower is better)

Spiral Segment 7

Duration 12.8 s, Accuracy Estimate 1.989 (lower is better)

Spiral Segment 8

Duration 14.4 s, Accuracy Estimate 1.997 (lower is better)

Spiral Segment 9

Duration 12.68 s, Accuracy Estimate 1.801 (lower is better)

Spiral Segment 10

Duration 10.0 s, Accuracy Estimate 2.354 (lower is better)

Elel

eDurationMean 0.348158
eDurationStd 0.0539948
eDurationStdnorm 0.155087
eDurationMedian 0.345
eDurationQuartdelta 0.045
eDurationQuartdeltanorm 0.130435
eDurationKurt 5.30359
eDurationTrenddiff -0.025
eDurationTrendratio 0.930556
eWidthMean 4.49834
eWidthStd 1.32808
eWidthStdnorm 0.295239
eWidthMedian 4.329
eWidthQuartdelta 1.872
eWidthQuartdeltanorm 0.432432
eWidthKurt 3.19389
eWidthTrenddiff -1.521
eWidthTrendratio 0.711111
eHeightMean 13.3534
eHeightStd 1.93214
eHeightStdnorm 0.144693
eHeightMedian 12.8115
eHeightQuartdelta 2.34
eHeightQuartdeltanorm 0.182648
eHeightKurt 2.84858
eHeightTrenddiff -1.989
eHeightTrendratio 0.860656
eAspectMean 0.338648
eAspectStd 0.094881
eAspectStdnorm 0.280176
eAspectMedian 0.313045
eAspectQuartdelta 0.122616
eAspectQuartdeltanorm 0.391689
eAspectKurt 2.28249
eAspectTrenddiff -0.0395004
eAspectTrendratio 0.885261
eSlantMean -0.260847
eSlantStd 0.145263
eSlantStdnorm -0.556887
eSlantMedian -0.271545
eSlantQuartdelta 0.207271
eSlantQuartdeltanorm -0.763302
eSlantKurt 2.31998
eSlantTrenddiff 0.0492424
eRtopMean 0.649472
eRtopStd 0.162926
eRtopStdnorm 0.25086
eRtopMedian 0.658915
eRtopQuartdelta 0.270833
eRtopQuartdeltanorm 0.411029
eRtopKurt 2.1355
eRtopTrenddiff 0.103365
eRbotMean 1.53901
eRbotStd 0.475642
eRbotStdnorm 0.309057
eRbotMedian 1.50496
eRbotQuartdelta 0.604167
eRbotQuartdeltanorm 0.40145
eRbotKurt 2.60486
eRbotTrenddiff 0.0868486
eRrightMean 0.823757
eRrightStd 0.0947785
eRrightStdnorm 0.115056
eRrightMedian 0.836296
eRrightQuartdelta 0.132025
eRrightQuartdeltanorm 0.157869
eRrightKurt 2.73354
eRrightTrenddiff 0.0125926
eRleftMean 0.567254
eRleftStd 0.0898328
eRleftStdnorm 0.158364
eRleftMedian 0.569817
eRleftQuartdelta 0.107533
eRleftQuartdeltanorm 0.188715
eRleftKurt 2.59993
eRleftTrenddiff -0.0511278
lDurationMean 0.465128
lDurationStd 0.0874228
lDurationStdnorm 0.187954
lDurationMedian 0.45
lDurationQuartdelta 0.11625
lDurationQuartdeltanorm 0.258333
lDurationKurt 2.70064
lDurationTrenddiff -0.065
lDurationTrendratio 0.868687
lWidthMean 5.055
lWidthStd 1.03582
lWidthStdnorm 0.204909
lWidthMedian 4.914
lWidthQuartdelta 1.053
lWidthQuartdeltanorm 0.214286
lWidthKurt 3.42502
lWidthTrenddiff 0.117
lWidthTrendratio 1.02381
lHeightMean 29.199
lHeightStd 3.48671
lHeightStdnorm 0.119412
lHeightMedian 29.133
lHeightQuartdelta 4.3875
lHeightQuartdeltanorm 0.150602
lHeightKurt 2.59452
lHeightTrenddiff -3.51
lHeightTrendratio 0.886792
lAspectMean 0.174495
lAspectStd 0.0360597
lAspectStdnorm 0.206651
lAspectMedian 0.172727
lAspectQuartdelta 0.0368602
lAspectQuartdeltanorm 0.213401
lAspectKurt 3.77389
lAspectTrenddiff 0.0338823
lAspectTrendratio 1.21835
lSlantMean -0.0764464
lSlantStd 0.0592521
lSlantStdnorm -0.77508
lSlantMedian -0.0761905
lSlantQuartdelta 0.0933411
lSlantQuartdeltanorm -1.2251
lSlantKurt 2.44233
lSlantTrenddiff 0.0791667
lRtopMean 0.733669
lRtopStd 0.134559
lRtopStdnorm 0.183406
lRtopMedian 0.756757
lRtopQuartdelta 0.199151
lRtopQuartdeltanorm 0.263164
lRtopKurt 2.64642
lRtopTrenddiff 0.169399
lRbotMean 1.24301
lRbotStd 0.429549
lRbotStdnorm 0.345571
lRbotMedian 1.16667
lRbotQuartdelta 0.486932
lRbotQuartdeltanorm 0.41737
lRbotKurt 7.20752
lRbotTrenddiff -0.391324
lRrightMean 0.87107
lRrightStd 0.0665206
lRrightStdnorm 0.0763665
lRrightMedian 0.873188
lRrightQuartdelta 0.0636122
lRrightQuartdeltanorm 0.0728504
lRrightKurt 4.50088
lRrightTrenddiff -0.00170246
lRleftMean 0.459175
lRleftStd 0.12663
lRleftStdnorm 0.275777
lRleftMedian 0.438163
lRleftQuartdelta 0.167138
lRleftQuartdeltanorm 0.381452
lRleftKurt 2.43523
lRleftTrenddiff -0.149793

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.974902
sumTouchScores 15.5984
meanMovementTime 0.549667
numTouches 16
undershootPercentage 6.25
overshootPercentage 6.25

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.896409
sumTouchScores 22.4102
meanMovementTime 0.784167
numTouches 25
undershootPercentage 4
overshootPercentage 8

ZigZag

numZigzags 5
timePerZigzagMean 12.184
timePerZigzagCoV 0.0406482
timePerZigzagSlope -0.00984898
meanError 2.65095
tremorFreq 6.34766
tremorRelPower 25.1099
tremorGyroAmpMean 0.0503497
tremorGyroAmpSlope 0.000707126
tremorGyroAmpCoV 0.344584
tremorCoordAmpMean 0.0927106
tremorCoordAmpSlope -0.00292083
tremorCoordAmpCoV 0.264419
tremorAccAmpMean 0.0777219
tremorAccAmpSlope -0.000304317
tremorAccAmpCoV 0.18746
tremorPcRelVar 0.759574
tremorPcX 0.0235545
tremorPcY -0.999723

ZigZag Segment 1

Duration 12.92 s, Accuracy Estimate 2.574 (lower is better)

ZigZag Segment 2

Duration 11.92 s, Accuracy Estimate 2.743 (lower is better)

ZigZag Segment 3

Duration 11.96 s, Accuracy Estimate 2.475 (lower is better)

ZigZag Segment 4

Duration 11.68 s, Accuracy Estimate 2.736 (lower is better)

ZigZag Segment 5

Duration 12.44 s, Accuracy Estimate 2.727 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 8.912
timePerZigzagCoV 0.0780892
timePerZigzagSlope -0.0444345
zigzagHeightMean 61.7511
zigzagHeightCoV 0.0417714
zigzagHeightSlope 0.0158717
meanError 0.039085
tremorFreq 6.34766
tremorRelPower 26.7236
tremorGyroAmpMean 0.0649893
tremorGyroAmpSlope 0.00593699
tremorGyroAmpCoV 0.397903
tremorCoordAmpMean 0.133569
tremorCoordAmpSlope -0.00301294
tremorCoordAmpCoV 0.363083
tremorAccAmpMean 0.100286
tremorAccAmpSlope -0.0017184
tremorAccAmpCoV 0.250207
tremorPcRelVar 0.83421
tremorPcX 0.0828338
tremorPcY 0.996563

ZigZag Offset Segment 1

Duration 9.96 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 2

Duration 8.88 s, Accuracy Estimate 0.032 (lower is better)

ZigZag Offset Segment 3

Duration 8.88 s, Accuracy Estimate 0.044 (lower is better)

ZigZag Offset Segment 4

Duration 8.84 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 5

Duration 8.0 s, Accuracy Estimate 0.051 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.77}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.53}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.8896079489711293}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.5012481315854453}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7656774390303933}